Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics
Journal of Clinical Pharmacy and Therapeutics, 05/25/2012
Brzakovic BB et al. – The efficacy and safety of lamotrigine may be altered by concomitant administration of carbamazepine and valproic acid. The models developed may be useful for estimating doses of lamotrigine for individual patients to minimize clinically significant interactions. Therapeutic monitoring is advisable when those drugs are used concomitantly.