Paracetamol toxicity: what would be the implications of a change in UK treatment guidelines?
European Journal of Clinical Pharmacology, 05/15/2012
McQuade DJ et al. – Both a 100 line and a 150/75 line would result in a large increase in the number of patients being treated and an associated increase in the costs of treatment. A single 150 mg/L treatment line would simplify treatment algorithms and lead to a similar number of patients being treated with NAC overall. A potential concern however is whether any of the high risk cases that would no longer be treated might develop significant hepatotoxicity. After consideration of the evidence for dual treatment lines, authors feel that these risks are small and that it is worth reconsidering a change of treatment recommendations to a single 150 line.