A Phase 1, Randomized, Placebo-Controlled, Dose-Escalation Study of an Anti-IL-13 Monoclonal Antibody in Healthy Subjects and Mild Asthmatics
British Journal of Clinical Pharmacology,  Clinical Article

Hodsman GP et al. – GSK679586 demonstrated dose–dependent pharmacological activity in the lungs of mild intermittent asthmatics. These findings, together with the favorable safety profile and advantageous PK characteristics of a monoclonal antibody (e.g. a long half–life supporting less frequent dosing), warrant further investigation of GSK679586 in a broader asthma patient population.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pharmacy

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pharmacy Articles

1 Commonly prescribed drug for lower back pain not effective University of Rochester Medical Center, December 12, 2014

2 Is the standard dose of amoxicillin-clavulanic acid sufficient? Full Text BMC Pharmacology & Toxicology, August 8, 2014    Free full text    Clinical Article

3 Single-dose oritavancin versus 7-10 days of vancomycin in the treatment of gram-positive acute bacterial skin and skin structure infections: The SOLO II Noninferiority Study Clinical Infectious Diseases, December 1, 2014    Clinical Article

4 New drug could make vaccines more effective in the elderly University of Oxford News, November 14, 2014

5 Widely used osteoporosis drugs may prevent breast, lung and colon cancers The Mount Sinai Hospital, December 3, 2014

6 Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers Full Text Drug Design, Development and Therapy, September 30, 2014    Free full text    Clinical Article

7 Vancomycin, metronidazole, or tolevamer for clostridium difficile infection: Results from two multinational, randomized, controlled trials Clinical Infectious Diseases, June 6, 2014    Clinical Article

8 Beyond statins: new lipid lowering strategies to reduce cardiovascular risk Current Atherosclerosis Reports, May 21, 2014    Review Article    Clinical Article

9 Use of proton pump inhibitors for the provision of stress ulcer prophylaxis: Clinical and economic consequences PharmacoEconomics, February 11, 2014    Clinical Article

10 Role of mineralocorticoid receptor antagonists in cardiovascular disease Circulation Research, January 16, 2015    Clinical Article

11 Daily aspirin use and prostate cancer–specific mortality in a large cohort of men with nonmetastatic prostate cancer Journal of Clinical Oncology, October 24, 2014    Clinical Article

12 Honey as an effective antimicrobial treatment for chronic wounds Full Text Chronic Wound Care Management and Research, August 21, 2014    Free full text    Review Article

13 Magnesium should be given to all children presenting to hospital with acute severe asthma Paediatric Respiratory Reviews, October 15, 2014    Clinical Article

14 A systematic review: Can one prescribe carbapenems to patients with IgE-mediated allergy to penicillins or cephalosporins? Clinical Infectious Diseases, July 25, 2014    Clinical Article

15 Prediction model for 30-day hospital readmissions among patients discharged receiving outpatient parenteral antibiotic therapy Full Text Clinical Infectious Diseases, January 30, 2014    Free full text    Clinical Article

16 New cholesterol guideline: LDL goals take backseat to statins Full Text American Pharmacists Association News, November 15, 2013    Free full text    Clinical Guideline

17 Impact of a new method of warfarin management on patient satisfaction, time, and cost Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, August 23, 2013    Clinical Article

18 Long-acting muscarinic antagonist use in adults with asthma: real-life prescribing and outcomes of add-on therapy with tiotropium bromide Full Text Journal of Asthma and Allergy, January 23, 2015    Free full text    Clinical Article

19 Optimizing medication use with a pharmacist-provided comprehensive medication management service for patients with psychiatric disorders Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, October 21, 2014    Clinical Article

20 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

Indexed Journals in Pharmacy: Expert Opinion in Pharmacotherapy, Formulary, U.S.Pharmacistmore

Looking for a physician job? Let us help!

Register now for our free job placement service.
A career consultant will contact you soon.
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List