The value of genetic polymorphisms to predict toxicity in metastatic colorectal patients with irinotecan-based regimens
Cancer Chemotherapy and Pharmacology,  Clinical Article

Lamas MJ et al. – The impact of increased risk of toxicity attributed to the UGT1A variants may be offset by irinotecan in clinical practice by dose reduction or the use of colony–stimulating factor.

Methods
  • Genomic DNA was genotyped for UGT1A1 (*28, *60 and *93) from all 101 patients, and irinotecan dose was 180mg/m2 every second week.
  • Clinical data were obtained by retrospective chart review.
  • The primary endpoint is to find out whether the pharmacogenetic test in the clinical practice may predict toxicity.

Results
  • Grade 3/4 diarrhea occurred in twelve patients and required dose reduction in six patients, and neutropenia reached grade 3/4 in 19 patients (only one patient with *28/*28 genotype).
  • The UGT1A1*93 seemed to relate with grade 3/4 neutropenia but only in the heterozygote state (G/A), p=0.071, and UGT1A*60 showed no association with neutropenia.
  • Twenty-eight percentage of patients required the use of G-CSF; 64.3 % of them harbored *1/*28 or *28/*28 genotypes, p=0.003.
  • Thirty-seven (36.6 %) patients required dose reduction of irinotecan and/or 5-FU owing to toxicity, mainly neutropenia and diarrhea.
  • No significant association was detected between *28, *60 and *93 UGT1A variants and severe irinotecan-associated hematologic or GI toxicity.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pharmacy

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pharmacy Articles

1 Precautionary labelling of foods for allergen content: Are we ready for a global framework? Full Text World Allergy Organization Journal, May 8, 2014    Free full text    Review Article

2 A pilot study to assess feasibility of value based pricing in Cyprus through pharmacoeconomic modelling and assessment of its operational framework: Sorafenib for second line renal cell cancer Full Text Cost Effectiveness and Resource Allocation, May 5, 2014    Free full text

3 Vancomycin, metronidazole, or tolevamer for clostridium difficile infection: Results from two multinational, randomized, controlled trials Clinical Infectious Diseases, June 6, 2014    Clinical Article

4 Maternal high-dose folic acid during pregnancy and asthma medication in the offspring Pharmacoepidemiology and Drug Safety, June 23, 2014    Clinical Article

5 Reprint of “Heated vegetable oils and cardiovascular disease risk factors” Vascular Pharmacology, June 4, 2014    Review Article

6 Diuretics in the treatment of hypertension. Part 2: loop diuretics and potassium-sparing agents Expert Opinion on Pharmacotherapy, March 17, 2014    Review Article

7 Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers European Journal of Clinical Pharmacology, June 12, 2014    Clinical Article

8 Cost-effectiveness of cranberries vs antibiotics to prevent urinary tract infections in premenopausal women: a randomized clinical trial PLOS ONE, April 15, 2014    Review Article

9 Economic evaluation of warfarin, dabigatran, rivaroxaban, and apixaban for stroke prevention in atrial fibrillation PharmacoEconomics, April 9, 2014    Clinical Article

10 The effectiveness of metoprolol versus atenolol on prevention of all-cause and cardiovascular mortality in a large Chinese population: A cohort study International Journal of Cardiology, June 27, 2014    Clinical Article

11 Prasugrel versus clopidogrel in patients with ST-segment elevation myocardial infarction according to timing of percutaneous coronary intervention JACC Cardiovascular Interventions, June 20, 2014    Clinical Article

12 New oral anticoagulants in patients with nonvalvular atrial fibrillation: a review of pharmacokinetics, safety, efficacy, quality of life, and cost effectiveness Full Text Drug Design, Development and Therapy, June 18, 2014    Free full text    Review Article

13 Efficacy of nebulised budesonide versus oral prednisolone in acute severe asthma The Indian Journal of Pediatrics, June 11, 2014    Clinical Article

14 HIV risk reduction with buprenorphine-naloxone or methadone: Findings from a randomized trial Journal of Acquired Immune Deficiency Syndromes, June 19, 2014    Clinical Article

15 Beyond statins: new lipid lowering strategies to reduce cardiovascular risk Current Atherosclerosis Reports, May 21, 2014    Review Article    Clinical Article

16 Aspirin desensitization in patients with aspirin-induced and aspirin-tolerant asthma: A double-blind study The Journal of Allergy and Clinical Immunology, June 13, 2014    Clinical Article

17 The administration of a loading dose of aspirin to patients presenting with acute myocardial infarction while receiving chronic aspirin treatment reduces thromboxane A2-dependent platelet reactivity Platelets, June 10, 2014    Clinical Article

18 Warfarin dosing and body mass index Annals of Pharmacotherapy, April 21, 2014    Clinical Article

19 Novel approaches to the development of targeted therapeutic agents for systemic lupus erythematosus Journal of Autoimmunity , June 24, 2014    Review Article

20 Single-dose intra-articular bupivacaine versus morphine after arthroscopic knee surgery: A meta-analysis of randomized-controlled studies The Clinical Journal of Pain, June 10, 2014    Clinical Article

Indexed Journals in Pharmacy: Expert Opinion in Pharmacotherapy, Formulary, U.S.Pharmacistmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close