A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma
Cancer,  Clinical Article

Nabors LB et al. – Cilengitide was well tolerated when combined with standard chemoradiation and may improve survival for patients newly diagnosed with glioblastoma multiforme regardless of MGMT methylation status. The authors concluded that, from an efficacy and safety standpoint, future trials of this agent in this population should use the 2000mg dose.

Methods
  • In total, 112 patients were accrued.
  • Eighteen patients received standard radiation and temozolomide with cilengitide in a safety run-in phase followed by a randomized phase 2 trial with 94 patients assigned to either a 500mg dose group or 2000mg dose group.
  • The trial was designed to estimate overall survival benefit compared with a New Approaches to Brain Tumor Therapy (NABTT) Consortium internal historic control and data from the published European Organization for Research and Treatment of Cancer (EORTC) trial EORTC 26981.

Results
  • Cilengitide at all doses studied was well tolerated with radiation and temozolomide.
  • The median survival was 19.7months for all patients, 17.4months for the patients in the 500mg dose group, 20.8months for patients in the 2000mg dose group, 30months for patients who had methylated O6-methylguanine-DNA methyltransferase (MGMT) status, and 17.4months for patients who had unmethylated MGMT status.
  • For patients aged ≤70years, the median survival and survival at 24months was superior to what was observed in the EORTC trial (20.7months vs 14.6months and 41% vs 27%, respectively; P=.008).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pharmacy

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pharmacy Articles

1 FDA approves new type of sleep drug, Belsomra Full Text FDA Press Announcements, August 14, 2014    Free full text

2 One injection stops diabetes in its tracks Salk Institute News, July 18, 2014

3 Antibiotic developed 50 years ago may be the key to fighting 'superbugs' University at Buffalo Health and Medicine News, June 19, 2014

4 FDA approves Afrezza to treat diabetes Full Text FDA Press Announcements, June 30, 2014    Free full text

5 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

6 Magnesium should be given to all children presenting to hospital with acute severe asthma Paediatric Respiratory Reviews, October 15, 2014    Clinical Article

7 New research indicates statin drugs must be taken properly Michigan State University Health News, July 22, 2014

8 Daily aspirin use and prostate cancer–specific mortality in a large cohort of men with nonmetastatic prostate cancer Journal of Clinical Oncology, October 24, 2014    Clinical Article

9 Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers Full Text Drug Design, Development and Therapy, September 30, 2014    Free full text    Clinical Article

10 Duke team brings life-saving function to ketchup packets Duke University Health & Medicine News, July 3, 2014

11 Is the standard dose of amoxicillin-clavulanic acid sufficient? Full Text BMC Pharmacology & Toxicology, August 8, 2014    Free full text    Clinical Article

12 Honey as an effective antimicrobial treatment for chronic wounds Full Text Chronic Wound Care Management and Research, August 21, 2014    Free full text    Review Article

13 Honey: a potential therapeutic agent for managing diabetic wounds Full Text Evidence-based Complementary and Alternative Medicine , October 16, 2014    Free full text    Clinical Article

14 Differences in composition of honey samples and their impact on the antimicrobial activities against drug multiresistant bacteria and pathogenic fungi Archives of Medical Research, October 3, 2014    Clinical Article

15 “Worm pill” could ease autoimmune disease symptoms Monash University News, August 11, 2014

16 Update on recommendations for use of herpes zoster vaccine Full Text Morbidity and Mortality Weekly Report, August 22, 2014    Free full text

17 Levomilnacipran: A new serotonin-norepinephrine reuptake inhibitor for the treatment of major depressive disorder Annals of Pharmacotherapy, July 25, 2014    Review Article    Clinical Article

18 Effect of reiki therapy on pain and anxiety in adults: an in-depth literature review of randomized trials with effect size calculations Pain Management Nursing, October 2, 2014    Clinical Article

19 Dapoxetine for premature ejaculation: an updated meta-analysis of randomized controlled trials Clinical Therapeutics, October 29, 2014    Clinical Article

20 What's more effective: Generic or brand-name statins? Brigham and Women's Hospital, September 16, 2014

Indexed Journals in Pharmacy: Expert Opinion in Pharmacotherapy, Formulary, U.S.Pharmacistmore