Clinical evaluation of hemorrhagic gastroduodenal ulcer in the elderly: is helicobacter pylori infection a risk factor for hemorrhage
Digestive Endoscopy,  Clinical Article

Domon K et al. – The observed lower prevalence of Helicobacter pylori infection among the elderly patients compared to the younger patients with hemorrhagic gastroduodenal ulcer suggests that other factors, such as non–steroidal anti–inflammatory drugs use and chronic renal failure, predispose the elderly to hemorrhagic ulcer.

Methods
  • A total of 353 patients with Forrest class I-IIa hemorrhagic gastroduodenal ulcer who underwent endoscopic hemostasis at the hospital between December 2004 and May 2010 were divided into two groups: one for those 75 years or older (old-old group; n = 71; age ≥75 years) and one for those younger than 75 years (younger group; n = 282; age <75 years).
  • Then, their demographic characteristics were compared.

Results
  • There were significantly more female patients, patients with underlying chronic renal failure and patients using non-steroidal anti-inflammatory drugs in the old-old group than in the younger group.
  • In addition, the prevalence of open-type atrophy in the background gastric mucosa was significantly higher in the old-old group.
  • Although more than half the patients in each group were infected with Helicobacter pylori, the prevalence was significantly higher in the younger group.
  • Of the patients who underwent endoscopic hemostasis only once, those in the old-old group constituted a significantly higher medical cost than those in the younger group.
  • Comparison of deaths between the two groups revealed that the old-old patients were more likely to develop severe complications associated with hematemesis, such as aspiration pneumonia.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pharmacy

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pharmacy Articles

1 FDA approves new type of sleep drug, Belsomra Full Text FDA Press Announcements, August 14, 2014    Free full text

2 One injection stops diabetes in its tracks Salk Institute News, July 18, 2014

3 Antibiotic developed 50 years ago may be the key to fighting 'superbugs' University at Buffalo Health and Medicine News, June 19, 2014

4 FDA approves Afrezza to treat diabetes Full Text FDA Press Announcements, June 30, 2014    Free full text

5 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

6 Magnesium should be given to all children presenting to hospital with acute severe asthma Paediatric Respiratory Reviews, October 15, 2014    Clinical Article

7 New research indicates statin drugs must be taken properly Michigan State University Health News, July 22, 2014

8 Daily aspirin use and prostate cancer–specific mortality in a large cohort of men with nonmetastatic prostate cancer Journal of Clinical Oncology, October 24, 2014    Clinical Article

9 Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers Full Text Drug Design, Development and Therapy, September 30, 2014    Free full text    Clinical Article

10 Duke team brings life-saving function to ketchup packets Duke University Health & Medicine News, July 3, 2014

11 Is the standard dose of amoxicillin-clavulanic acid sufficient? Full Text BMC Pharmacology & Toxicology, August 8, 2014    Free full text    Clinical Article

12 Honey as an effective antimicrobial treatment for chronic wounds Full Text Chronic Wound Care Management and Research, August 21, 2014    Free full text    Review Article

13 Honey: a potential therapeutic agent for managing diabetic wounds Full Text Evidence-based Complementary and Alternative Medicine , October 16, 2014    Free full text    Clinical Article

14 Differences in composition of honey samples and their impact on the antimicrobial activities against drug multiresistant bacteria and pathogenic fungi Archives of Medical Research, October 3, 2014    Clinical Article

15 “Worm pill” could ease autoimmune disease symptoms Monash University News, August 11, 2014

16 Update on recommendations for use of herpes zoster vaccine Full Text Morbidity and Mortality Weekly Report, August 22, 2014    Free full text

17 Levomilnacipran: A new serotonin-norepinephrine reuptake inhibitor for the treatment of major depressive disorder Annals of Pharmacotherapy, July 25, 2014    Review Article    Clinical Article

18 Effect of reiki therapy on pain and anxiety in adults: an in-depth literature review of randomized trials with effect size calculations Pain Management Nursing, October 2, 2014    Clinical Article

19 Dapoxetine for premature ejaculation: an updated meta-analysis of randomized controlled trials Clinical Therapeutics, October 29, 2014    Clinical Article

20 What's more effective: Generic or brand-name statins? Brigham and Women's Hospital, September 16, 2014

Indexed Journals in Pharmacy: Expert Opinion in Pharmacotherapy, Formulary, U.S.Pharmacistmore