Warfarin-amiodarone drug-drug interactions: determination of [i]u/ki,u for amiodarone and its plasma metabolites

Clinical Pharmacology & Therapeutics, 03/26/2012

From these ratios, authors predict that a minor metabolite of amiodarone, namely, N,N–didesethylamiodarone (DDEA), is a major contributor to the interaction between warfarin and amiodarone.

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