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Circulating CSF-1 Promotes Monocyte and Macrophage Phenotypes that Enhance Lupus Nephritis
Journal of the American Society of Nephrology, 11/20/09
Menke J et al. – The found increased levels of CSF–1 in the serum, urine, and kidneys of patients with lupus compared with healthy controls. Serum and urine CSF–1 levels correlated with lupus activity, and intrarenal CSF–1 expression correlated with the histopathology activity index of lupus nephritis. Circulating CSF–1 is a potential therapeutic target for lupus nephritis.
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