Pharmacy Medical News about Critical Illness Remifentanil

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Use of remifentanil as a sedative agent in critically ill adult patients: a meta-analysis
Anaesthesia, 11/10/09

Tan JA et al. – This meta–analysis examined the benefits of using remifentanil as a sedative agent in critically ill patients. A total of 11 randomised controlled trials, comparing remifentanil with another opioid or hypnotic agent in 1067 critically ill adult patients, were identified from the Cochrane controlled trials register and EMBASE and MEDLINE databases, and subjected to meta–analysis. Remifentanil was associated with a reduction in the time to tracheal extubation after cessation of sedation. Remifentanil was, however, not associated with a significant reduction in mortality, duration of mechanical ventilation, length of intensive care unit stay, and risk of agitation when compared to an alternative sedative or analgesic agent. The current evidence does not support the routine use of remifentanil as a sedative agent in critically ill adult patients.

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Practice variability in the assessment and treatment of critical illness-related corticosteroid insufficiency
Journal of Critical Care, 10/02/09 Relevance Score: 70%

Poor functional recovery after a critical illness: A longitudinal study
Journal of Rehabilitation Medicine, 11/13/09 Relevance Score: 67%

Understanding, recognizing, and managing chronic critical illness syndrome
Journal of the American Academy of Nurse Practitioners, 11/05/09 Relevance Score: 67%

Severe hypocholesterolemia in surgical patients, sepsis, and critical illness
Journal of Critical Care, 10/16/09 Relevance Score: 67%

Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients
New England Journal of Medicine, 10/22/09 Relevance Score: 66%