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Use of Fertility Drugs and Risk of Uterine Cancer: Results From a Large Danish Population-based Cohort Study
American Journal of Epidemiology, 11/04/09

Jensen A et al. – Ever use of any fertility drug was not associated with uterine cancer risk. However, ever use of gonadotropins (follicle–stimulating hormone and human menopausal gonadotropin) increased uterine cancer risk; the risk was primarily observed after 10 years of follow–up. Furthermore, uterine cancer risk increased with number of cycles of use for clomiphene and human chorionic gonadotropin but not for other gonadotropins. Use of gonadotropin–releasing hormone analogs was not associated with risk. Gonadotropins, and possibly clomiphene and human chorionic gonadotropin, may increase the risk of uterine cancer, with higher doses and longer follow–up leading to greater risk.

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