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See Latest ArticlesPhysiologically-Based Pharmacokinetic Model of Mechanism-Based Inhibition of CYP3A by Clarithromycin
Drug Metabolism and Disposition, 11/06/09
Quinney SK et al. – This semi–PBPK model incorporating CYP3A inactivation in the intestine and liver accurately predicts the nonlinear pharmacokinetics of clarithromycin and the DDI observed between clarithromycin and midazolam. Further, this model framework can be applied to other mechanism–based inhibitors.
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