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Amir E et al. – Bevacizumab, a humanized monoclonal antibody against the vascular endothelial growth factor, when added to cytotoxic chemotherapy, was the first treatment to prolong the overall survival of patients with advanced NSCLC beyond 12 months, a significant breakthrough in the management of advanced NSCLC. Small–molecule tyrosine kinase inhibitors and alternative antivascular strategies such as VEGF–trap and vascular disrupting agents are also being investigated and have shown promise in clinical trials.

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