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Structure and function of heterotrimeric g protein-regulated rho guanine nucleotide exchange factors
Molecular Pharmacology, 11/02/09
Aittaleb M et al. – Atomic structures have recently been determined for several of these RhoGEFs and their G protein complexes, providing fresh insight into the molecular mechanisms of signal transduction between GPCRs and small molecular weight G proteins. This review covers what is currently known about the structure, function, and regulation of these recently recognized effectors of heterotrimeric G proteins.
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