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Ruf BM et al. – A review of the literature provides strong evidence that 5–HT1B receptors and related factors such as p11 are involved in the pathophysiology of depression. The following explores possible factors which may render the 5–HT1B receptor dysfunctional, resulting in susceptibility to depression. Implications of using the 5– HT1B receptor as a biomarker for vulnerability to MDD are discussed.


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