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Prospect of a Dopamine Contribution in the Next Generation of Antidepressant Drugs: The Triple Reuptake Inhibitors
Current Drug Targets, 10/30/09
Guiard BP et al. – It is well established that the increase in central dopaminergic transmission regulates the neuronal activity of 5–HT and NE in the dorsal raphe (DR) and locus coeruleus, respectively, while in turn, the ventral tegmental area, is sensitive to changes in 5–HT and NE release. This review synthetizes the pertinent litterature, focusing on the contribution of DA, to illustrate the rationale for designing improved antidepressants.
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