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Treating Gram-positive infections: vancomycin update and the whys, wherefores and evidence base for continuous infusion of anti-Gram-positive antibiotics
Current Opinion in Infectious Diseases, 11/02/09
Chua K et al. – Vancomycin remains an important first–line antimicrobial for treatment of serious methicillin–resistant S. aureus infections; however, a detailed analysis of isolate susceptibility and appropriate dosing are important. Although continuous infusion of some anti–Gram–positive antimicrobials may provide theoretical benefits, clinical trials demonstrating superiority in outcomes are uncommon. Use of continuous infusion may, however, provide practical advantages in patients on home intravenous antibiotics.
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