Pharmacy

Your Article Summary

See Latest Articles

Comparison of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention
Vascular Health and Risk Management, 10/22/09

Norgard NB et al. – Clopidogrel, when added to aspirin, has demonstrated considerable success at reducing thrombotic complications of ACS and/or PCI compared to aspirin alone and is standard of care for the management of patients with ACS and in patients undergoing PCI. Prasugrel is a novel thienopyridine antiplatelet agent recently approved for the treatment of patients with ACS undergoing PCI. Prasugrel provides greater and more consistent platelet inhibition than clopidogrel due to earlier and more extensive formation of its active metabolite. The enhanced platelet inhibition with prasugrel led to a reduction in major adverse cardiovascular events in patients with moderate to high risk ACS scheduled for PCI in the phase 3 TRITON–TIMI 38 trial. This benefit was seen more in patients suffering a STEMI and those with diabetes. However, this reduction in events was met with a significant increase in the risk of bleeding which overcame prasugrel’s benefit in certain groups.

Related Articles

See all related articles

Dual antiplatelet therapy in coronary artery disease: A case-based approach
Cleveland Clinic Journal of Medicine, 11/04/09    Relevance Score: 99%

Ticagrelor demonstrated greater efficacy over clopidogrel in the most urgent clinical setting: Patients with ST-Segment Elevation Myocardial Infarction and planned Percutaneous Coronary Intervention
AstraZeneca, 11/16/09    Relevance Score: 98%

Predictive Values of Post-Treatment Adenosine Diphosphate–Induced Aggregation and Vasodilator-Stimulated Phosphoprotein Index for Stent Thrombosis After Acute Coronary Syndrome in Clopidogrel-Treated Patients
The American Journal of Cardiology, 10/15/09    Relevance Score: 98%

Acute Coronary Syndromes: Diagnosis and Management, Part II
Mayo Clinic Proceedings, 11/03/09    Relevance Score: 97%

Management of Spontaneous Coronary Artery Dissection: Review of the Literature and Discussion Based on a Series of 12 Young Women with Acute Coronary Syndrome
Cardiology, 10/12/09    Relevance Score: 97%

Today in Cardiac/Hypertension...keeping you current

Receive free subspecialty "5-minute updates" via email

Benefits and risks associated with (beta)-blocker prophylaxis in noncardiac surgery
American Journal of Health-System Pharmacy, 03/18/10

Drug-Induced QTc-Interval Prolongation in the Intensive Care Unit: Incidence and Predictors
Journal of Pharmacy Practice, 03/18/10

Targeting the pentose phosphate pathway in syndrome X-related cardiovascular complications
Drug Development Research, 03/18/10

 See all of Cardiac/Hypertension