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See Latest ArticlesSusceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure
Pharmacogenetics and genomics, 10/30/09
Golka K et al. – The authors analysed a hospital–based case–control series not selected for occupational exposure, rs9642880[T] was influential, in contrast to GSTM1 0/0. However, in a case–control series of patients that have been occupationally exposed to aromatic amines and polycyclic aromatic hydrocarbons, rs9642880[T] was not influential but GSTM1 0/0 was significantly associated with bladder cancer risk. Therefore, the degree to which rs9642880[T] and GSTM1 0/0 confer susceptibility to urinary bladder cancer seems to depend on the extent of exposure to urinary bladder carcinogens.
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