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Contribution of the different UDP-glucuronosyltransferase isoforms to buprenorphine and norbuprenorphine metabolism and relationship with the main UGT polymorphisms in a bank of human liver microsomes
Drug Metabolism and Disposition, 10/21/09
Rouguieg K et al. – The glucuronidation of BUP and Nor–BUP was examined using human liver microsomes and heterologously expressed UGTs. The individual contribution of UGT isoforms was estimated using enzyme kinetic experiments combined with the relative activity factor. This study represents a functional basis for further clinical pharmacogenetic studies.
Today in Basic Science...keeping you current
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Opiate-induced hypernociception and chemokine receptors
Neuropharmacology, 11/10/09
Ketorolac But Not Morphine Exerts Inflammatory and Metabolic Effects in Synovial Membrane After Knee Arthroscopy: A Double-Blind Randomized Prospective Study Using the Microdialysis Technique
Regional Anesthesia and Pain Medicine, 11/04/09
Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1
Current Drug Targets, 11/03/09
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Salix Receives FDA Marketing Approval for Metozolv
Salix Pharmaceuticals, 09/10/09
Methotrexate for maintenance of remission in Crohn's disease
Cochrane Reviews, 10/27/09
Management of chronic hepatitis C patients who have relapsed or not responded to pegylated interferon alfa plus ribavirin
Journal of Viral Hepatitis, 11/09/09
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