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Influence of Antidrug Antibodies on Plectasin Efficacy and Pharmacokinetics
Antimicrobial Agents and Chemotherapy, 11/04/09
Brinch KS et al. – Plectasin is a 4.4–kDa antimicrobial peptide with the potential to be a treatment of infections caused by gram–positive bacteria. Since plectasin is a large molecule compared to conventional antibiotics, the development of antidrug antibodies (ADAs) could be anticipated. The immunogenic properties of plectasin were assessed through immunization studies.
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