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See Latest ArticlesEffects of rifampicin on the pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects
British Journal of Clinical Pharmacology, 10/22/09
Nassr N et al. – Co–administration of rifampicin and roflumilast led to a reduction in total PDE4 inhibitory activity of roflumilast by about 58%. The use of potent cytochrome P450 inducers may reduce the therapeutic effect of roflumilast.
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