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See Latest ArticlesEvaluation of Cynomolgus Monkey PXR, Primary Hepatocyte and In Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction
Drug Metabolism and Disposition, 10/21/09
Kim S et al. – The results demonstrate that the cynomolgus monkey can be a predictive in vivo animal model of PXR–mediated induction of human CYP3A4 and can provide a useful assessment of the resulting pharmacokinetic changes of affected drugs.
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