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MacGregor AE et al. – During treatment of up to 12 perimenstrual periods over a 12– to 15–month period, the safety and tolerability of frovatriptan for short–term prevention of menstrual migraine was similar to that observed with acute use of triptans. Adverse events were generally mild or moderate in severity, there was no evidence of an increased risk of cardiovascular adverse events relative to acute treatment, and rebound headache was not evident. A short–term regimen with frovatriptan presents a safe and viable treatment option for preventing predictable migraine such as menstrual migraine.

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