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Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance
Clinical Pharmacokinetics, 10/15/09

Zhou SF – Concordant genotype–phenotype correlation provides a basis for predicting the phenotype based on genetic testing, which has the potential to achieve optimal pharmacotherapy. However, genotype testing for CYP2D6 is not routinely performed in clinical practice and there is uncertainty regarding genotype–phenotype, gene–concentration and gene–dose relationships.

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Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
Drug Metabolism and Disposition, 11/12/09 Relevance Score: 84%

Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population
Carcinogenesis, 10/08/09 Relevance Score: 84%

Acute Kidney Injury in Patients with Inactive Cytochrome P450 Polymorphisms
Renal Failure, 10/30/09 Relevance Score: 83%

How important is intestinal cytochrome P450 3A metabolism
Trends in Pharmacological Sciences, 10/14/09 Relevance Score: 83%