Pharmacy Medical News about Drug Interactions

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The Paradox of Caffeine-Zolpidem Interaction: A Network Analysis
Current Drug Targets, 10/23/09

Myslobodsky M et al. – The present overview is centered on the possibility that caffeine potentiation of zolpidem sedation does not involve a centralized interaction of specific neurotransmitters, but rather is contributed by its antioxidant capacity. It is proposed that by modifying the cellular redox state, caffeine ultimately reduces the pool of reactive oxygen species, thereby increasing the bioavailability of endogenous melatonin for interaction with zolpidem. This side effect of caffeine encourages further studies of multiple antioxidants as an attractive way to potentially increasing somnolence.

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An evidence-based assessment of the clinical significance of drug-drug interactions between disease-modifying antirheumatic drugs and non-antirheumatic drugs according to rheumatologists and pharmacists
Clinical Therapeutics, 10/15/09 Relevance Score: 72%

Quantitative prediction and clinical observation of a cyp3a inhibitor-based drug-drug interactions with mln3897, a potent ccr1 antagonist
Journal of Pharmacology and Experimental Therapeutics, 11/12/09 Relevance Score: 69%

Prediction of Human Drug and Drug Interactions from Time-Dependent Inactivation of CYP3A4 in Primary Hepatocytes Using a Population-Based Simulator
Drug Metabolism and Disposition, 10/06/09 Relevance Score: 69%

Human Mesenchymal Stem Cells and Immunosuppressive Drug Interactions in Allogeneic Responses: An In Vitro Study Using Human Cells
Transplantation Proceedings, 11/13/09 Relevance Score: 68%

Clinically Significant Adverse Events from a Drug Interaction Between Quetiapine and Atazanavir-Ritonavir in Two Patients
Pharmacotherapy, 10/27/09 Relevance Score: 68%