Pharmacy Medical News about Morphine Hyaluronoglucosaminidase rHuPH20

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The INFUSE-Morphine IIB Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneous Morphine in Healthy Volunteers
Journal of Pain and Symptom Management, 10/13/09

Thomas JR et al. – In this Phase IV, double–blind, randomized, crossover study, 18 healthy adults received a single dose of 2mg morphine SC with 150U of recombinant human hyaluronidase (rHuPH20), SC with 0.9% normal saline, or IV on three consecutive days...Coadministration of morphine with rHuPH20 appeared safe and well tolerated. Compared with SC morphine alone, rHuPH20 shortens morphine time to maximum plasma concentration (Tmax) and raises mean maximum plasma morphine concentration (Cmax) in healthy adults, without changing the extent of exposure.

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The INFUSE Morphine Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneously Administered Morphine in Patients with Advanced Illness
Journal of Pain and Symptom Management, 10/13/09 Relevance Score: 82%

Comparison of the effect of adding remifentanil to patient-controlled tramadol or morphine for postoperative analgesia after major abdominal surgery
Journal of Opioid Management, 11/03/09 Relevance Score: 47%

Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: a randomized double-blinded study
Journal of Palliative Medicine, 10/19/09 Relevance Score: 46%

Analysis of individual patient data from clinical trials: epidural morphine for postoperative pain
British Journal of Anesthesia, 11/05/09 Relevance Score: 45%

Central Sensory-Motor Deficit After Uneventful Single-Dose Spinal Morphine Administration in a Patient with Preexisting Migraine Headaches
Anesthesia & Analgesia, 10/21/09 Relevance Score: 44%