Pharmacy Medical News about Morphine Hyaluronoglucosaminidase rHuPH20

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The INFUSE Morphine Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneously Administered Morphine in Patients with Advanced Illness
Journal of Pain and Symptom Management, 10/13/09

Thomas JR et al. – This Phase IIIB, double–blind, randomized, placebo–controlled crossover study compared the pharmacokinetics, safety, and tolerability of morphine administered SC with and without 150U of recombinant human hyaluronidase (rHuPH20) with those of intravenous (IV) morphine administration in 13 patients in a hospice or palliative care setting...Morphine plus rHuPH20 appeared to be safe and well tolerated. In patients requiring opioid analgesia, SC morphine plus rHuPH20 provides pharmacokinetic characteristics that are superior to those of SC morphine alone. These positive results warrant further studies on analgesic efficacy of morphine delivered with rHuPH20.

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The INFUSE-Morphine IIB Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneous Morphine in Healthy Volunteers
Journal of Pain and Symptom Management, 10/13/09 Relevance Score: 82%

Comparison of the effect of adding remifentanil to patient-controlled tramadol or morphine for postoperative analgesia after major abdominal surgery
Journal of Opioid Management, 11/03/09 Relevance Score: 47%

Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: a randomized double-blinded study
Journal of Palliative Medicine, 10/19/09 Relevance Score: 46%

Analysis of individual patient data from clinical trials: epidural morphine for postoperative pain
British Journal of Anesthesia, 11/05/09 Relevance Score: 45%

Central Sensory-Motor Deficit After Uneventful Single-Dose Spinal Morphine Administration in a Patient with Preexisting Migraine Headaches
Anesthesia & Analgesia, 10/21/09 Relevance Score: 44%