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Tan P–H et al. – In this review, the authors will discuss these painrelated RNAi studies. The authors will also compare the advantages and disadvantages of RNAi with antisense knockdown, because antisense ligodeoxynucleotides have been extensively used for target validation in pain research. Although in vivo delivery of siRNA remains to be a challenge, RNAi has a great potential to become a major therapeutic tool for pain management.

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