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Singh–Franco D et al. – In the studies reviewed, LCZ 5 mg/d was effective in reducing symptoms of PAR, SAR, and CIU and improving QoL, with an acceptable tolerabili–ty profile. There is a need for studies of longer durations, head–to–head comparisons against other anti–histamines, drug–interaction studies, safety studies in infants, and cost–effectiveness analyses.


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