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Rinaldi F et al. – The authors describe three patients suffering from a very active form of relapsing–remitting multiple sclerosis (MS), who experienced severe disease worsening, associated with a marked increase in brain inflammation, a few days after the first administration of natalizumab. Relapsing–remitting MS patients having had a recent relapse should be treated with natalizumab only after achieving complete clinical and radiological remission.

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