Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Statins and cancer risk
Your Article Summary
See Latest ArticlesDietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention
The Journal of Nutrition, 10/08/09
Ho E et al. – The authors have previously found that sulforaphane (SFN), a compound found in cruciferous vegetables, inhibits HDAC activity in human colorectal and prostate cancer cells. Based on the similarity of SFN metabolites and other phytochemicals to known HDAC inhibitors, the authors previously demonstrated that sulforaphane acted as an HDAC inhibitor in the prostate, causing enhanced histone acetylation, derepression of P21 and Bax, and induction of cell cycle arrest/apoptosis, leading to cancer prevention. The ability of SFN to target aberrant acetylation patterns, in addition to effects on phase 2 enzymes, may make it an effective chemoprevention agent. These studies are important because of the potential to qualify or change recommendations for high–risk prostate cancer patients and thereby increase their survival through simple dietary choices incorporating easily accessible foods into their diets. These studies also will provide a strong scientific foundation for future large–scale human clinical intervention studies.
Related Articles
Raising HDL cholesterol in women
International Journal of Women's Health, 11/18/09
Relevance Score: 79%
Prostate Cancer Survivorship: Prevention and Treatment of the Adverse Effects of Androgen Deprivation Therapy
Journal of General Internal Medicine, 10/26/09
Relevance Score: 79%
Physical Activity's Impact on the Association of Fat and Fiber Intake With Survival After Breast Cancer
American Journal of Epidemiology, 10/23/09
Relevance Score: 79%
Clinicopathological Study of Regressed Testicular Tumors (Apparent Extragonadal Germ Cell Neoplasms)
The Journal of Urology, 10/22/09
Relevance Score: 79%
Nutrition Guidelines for Cancer Prevention: More Than Just Food for Thought
Geriatrics & Aging, 10/19/09
Relevance Score: 79%
Today in Men`s Health...keeping you current
Receive free subspecialty "5-minute updates" via email
Phase II study of paclitaxel and vinorelbine (Pacl-Vin) in hormone-refractory metastatic prostate cancer: double tubulin targeting
Internal Medicine Journal, 03/19/10
Serum Phosphorus Levels and the Spectrum of Ankle-Brachial Index in Older Men
American Journal of Epidemiology, 03/18/10
Rapid loss of appendicular skeletal muscle mass is associated with higher all-cause mortality in older men: the prospective MINOS study
American Journal of Clinical Nutrition, 03/18/10
Today in Preventive/Nutrition...keeping you current
Receive free subspecialty "5-minute updates" via email
Organisational travel plans for improving health
Cochrane Reviews, 03/19/10
beta-Carotene Conversion to Vitamin A Decreases As the Dietary Dose Increases in Humans
The Journal of Nutrition, 03/19/10
Zinc Influences the Innate Immune Responses in Children with Enterotoxigenic Escherichia coli-Induced Diarrhea
The Journal of Nutrition, 03/19/10
Today in Alternative Therapies...keeping you current
Receive free subspecialty "5-minute updates" via email
Leech Therapy for Symptomatic Relief of Cancer Pain
Pain Medicine, 03/17/10
How should complementary and alternative medicine be taught to medical students in Switzerland? A survey of medical experts and students
Medical Teacher, 03/16/10
Effects of a 6-Week, Individualized, Supervised Exercise Program for People With Bleeding Disorders and Hemophilic Arthritis
Physical Therapy, 03/09/10
Today in Renal/Urologic...keeping you current
Receive free subspecialty "5-minute updates" via email
Phase II study of paclitaxel and vinorelbine (Pacl-Vin) in hormone-refractory metastatic prostate cancer: double tubulin targeting
Internal Medicine Journal, 03/19/10
DNA methylation of HOXD3 as a marker of prostate cancer progression
Laboratory Investigation, 03/19/10
Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets
Laboratory Investigation, 03/19/10
Today in Hematology/Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Intrathecal Catheter-Syringe Adaptor for Short-Term Intrathecal Analgesia with an Externalized Pump: A Case Report
Pain Physician, 03/19/10
Phase II study of paclitaxel and vinorelbine (Pacl-Vin) in hormone-refractory metastatic prostate cancer: double tubulin targeting
Internal Medicine Journal, 03/19/10
Polycythemia vera
Internal and Emergency Medicine, 03/19/10
Today in Preventive Medicine...keeping you current
Receive free subspecialty "5-minute updates" via email
Organisational travel plans for improving health
Cochrane Reviews, 03/19/10
Meta-Synthesis of Health Behavior Change Meta-Analyses
American Journal of Public Health, 03/19/10
Dietary meat fats and burden of cardiovascular disease risk factors, in the elderly; a report from the MEDIS study
Lipids in Health and Disease, 03/19/10
Today in Hematology/Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Intrathecal Catheter-Syringe Adaptor for Short-Term Intrathecal Analgesia with an Externalized Pump: A Case Report
Pain Physician, 03/19/10
Phase II study of paclitaxel and vinorelbine (Pacl-Vin) in hormone-refractory metastatic prostate cancer: double tubulin targeting
Internal Medicine Journal, 03/19/10
Polycythemia vera
Internal and Emergency Medicine, 03/19/10
Today in Nutrition...keeping you current
Receive free subspecialty "5-minute updates" via email
beta-Carotene Conversion to Vitamin A Decreases As the Dietary Dose Increases in Humans
The Journal of Nutrition, 03/19/10
Trends in overweight and obese adults in Malaysia (1996–2009): a systematic review
Obesity Reviews, 03/19/10
Obesity Reduction Black Intervention Trial (ORBIT): 18-Month Results
Obesity, 03/19/10
Today in Preventive Medicine...keeping you current
Receive free subspecialty "5-minute updates" via email
Organisational travel plans for improving health
Cochrane Reviews, 03/19/10
Meta-Synthesis of Health Behavior Change Meta-Analyses
American Journal of Public Health, 03/19/10
Early-life determinants of overweight and obesity: a review of systematic reviews
Obesity Reviews, 03/19/10
Today in Hematology/Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Intrathecal Catheter-Syringe Adaptor for Short-Term Intrathecal Analgesia with an Externalized Pump: A Case Report
Pain Physician, 03/19/10
Phase II study of paclitaxel and vinorelbine (Pacl-Vin) in hormone-refractory metastatic prostate cancer: double tubulin targeting
Internal Medicine Journal, 03/19/10
Polycythemia vera
Internal and Emergency Medicine, 03/19/10
Today in Preventive Medicine...keeping you current
Receive free subspecialty "5-minute updates" via email
Organisational travel plans for improving health
Cochrane Reviews, 03/19/10
Meta-Synthesis of Health Behavior Change Meta-Analyses
American Journal of Public Health, 03/19/10
Early-life determinants of overweight and obesity: a review of systematic reviews
Obesity Reviews, 03/19/10
Article Search
Sponsor
Sponsor