Pharmacy Medical News about Hypertension Adrenergic alpha-Antagonists

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Blood pressure lowering efficacy of alpha blockers for primary hypertension
Cochrane Reviews, 10/09/09

Heran BS et al. – The authors found only 10 trials studying the blood pressure lowering ability of 4 different alpha blockers in 1175 participants. Based on the limited number of published RCTs, the BP lowering effect of alpha blockers is modest; the estimate of the magnitude of trough BP lowering of –8/–5 mmHg is likely an overestimate. There are no clinically meaningful BP lowering differences between different alpha blockers. The review did not provide a good estimate of the incidence of harms associated with alpha blockers because of the short duration of the trials and the lack of reporting of adverse effects in many of the trials.

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