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See Latest ArticlesIdentification of Multiple Glutathione Conjugates of Nomifensine in Liver Microsomes and Hepatocyte Preparations: Evidence of the Bioactivation of Nomifensine
Drug Metabolism and Disposition, 10/09/09
Yu J et al. – Both pathways contributed significantly to the formation of the GSH adducts in human and monkey liver microsomes. The bioactivation pathways proposed here account for the formation of the observed GSH conjugates. These investigations have confirmed that the aniline and the arene groups in nomifensine as potential toxicophores capable of generating reactive intermediates.
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