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Tamoxifen-induced adduct formation and cell stress in human endometrial glands
Drug Metabolism and Disposition, 10/09/09
Andersson HL et al. – The co–localization of [3H]tamoxifen adducts, expression of GRP78, caspase 3 and tamoxifen–metabolizing enzymes in human glandular and surface epithelia suggest a local bioactivation of tamoxifen at these sites and that epithelial cells are early target sites for tamoxifen–induced cell stress.
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