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Merchant N et al. – Significant improvements were seen in arterial compliance with nebivolol treatment as measured by aortic augmentation index and time to wave reflection. Nebivolol treatment improved endothelial function as measured by flow–mediated dilation. Levels of erythrocyte cellular superoxide dismutase increased with nebivolol, indirectly suggesting increased bioavailability of nitric oxide. Monotherapy with nebivolol in obese, hypertensive African Americans results in significant systolic and diastolic BP reduction by mechanisms that include improved vascular function and compliance.

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