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Discovery, mechanisms of action and combination therapy of artemisinin
Expert Review of Anti-infective Therapy, 10/16/09
Cui L et al. – Studies at the Thai–Cambodian border, a historical epicenter of multidrug resistance, have detected reduced susceptibility to artemisinins as manifested by prolonged parasite–clearance times, raising considerable concerns on resistance development. Despite this significance, there is still controversy on the mode of action of artemisinins. Although a number of potential cellular targets of artemisinins have been proposed, they remain to be verified experimentally.
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