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See Latest ArticlesSwitching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics
Modern Rheumatology, 10/08/09
Kawashiri S et al. – The short-term effects of the anti-interleukin-6 (IL-6) receptor antibody tocilizumab (TCZ) in six patients with rheumatoid arthritis (RA) who had been refractory to tumor necrosis factor (TNF) antagonist therapy were evaluated. Although physicians need to watch for infectious adverse events, these data indicate that TCZ is effective for treating RA patients refractory to TNF antagonists.
Methods- evaluated the short-term effects of IL-6 receptor antibody TCZ in 6 patients with RA who had been refractory to TNF antagonist therapy
- All subjects were considered to be secondary nonresponders to TNF antagonists as decided by each physician
- Disease Activity Score of 28 Joints (DAS28) improved slowly by TCZ compared with TNF antagonist therapy, significantly decreased at 24 weeks
- 1 patient achieved DAS28 remission [DAS28–erythrocyte sedimentation rate (ESR) < 2.60, and 5 of 6 patients showed good or moderate clinical response
- Change in clinical Disease Activity Index similar to that of the DAS28–ESR
- Serum level of matrix metalloproteinase-3 (MMP-3), a marker for synovial overgrowth, also significantly decreased after treatment (518 ± 567 at baseline, 141 ± 90 ng/ml at 24 weeks)
- 1 patient discontinued TCZ because of tuberculous peritonitis
Today in Clinical Pharmacology...keeping you current
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On-treatment serum HBsAg level is predictive of sustained off-treatment virologic response to telbivudine in HBeAg-positive chronic hepatitis B patients
Journal of Clinical Virology, 03/19/10
Diagnostic Efficacy of the Secretin Stimulation Test for the Zollinger-Ellison Syndrome: An Intra-Individual Comparison Using Different Dosages in Patients and Controls
Pancreatology, 03/19/10
Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1
The Journal of Antibiotics, 03/19/10
Today in Clinical Pharmacology...keeping you current
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On-treatment serum HBsAg level is predictive of sustained off-treatment virologic response to telbivudine in HBeAg-positive chronic hepatitis B patients
Journal of Clinical Virology, 03/19/10
Diagnostic Efficacy of the Secretin Stimulation Test for the Zollinger-Ellison Syndrome: An Intra-Individual Comparison Using Different Dosages in Patients and Controls
Pancreatology, 03/19/10
Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1
The Journal of Antibiotics, 03/19/10
Today in Rheumatology...keeping you current
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Pegloticase for chronic gout
Cochrane Reviews, 03/18/10
Gout, Hyperuricemia, and Parkinson’s Disease: A Protective Effect
Current Rheumatology Reports, 03/18/10
Management of inflammatory arthritis in older people
Reviews in Clinical Gerontology, 03/18/10
Today in Clinical Pharmacology...keeping you current
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Pegloticase for chronic gout
Cochrane Reviews, 03/18/10
Treatment of Osteoarthritis of the Ankle by Intra-articular Injections of Hyaluronic Acid
Journal of the American Podiatric Medical Association, 03/18/10
Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions
Modern Rheumatology, 03/18/10
Today in Rheumatoid Arthritis...keeping you current
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New low-field extremity MRI, compacTscan: comparison with whole-body 1.5 T conventional MRI
Modern Rheumatology, 03/18/10
Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions
Modern Rheumatology, 03/18/10
Decreased circulating CD28-negative T cells in patients with rheumatoid arthritis treated with abatacept are correlated with clinical response
Journal of Rheumatology, 03/18/10
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