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See Latest ArticlesTherapeutic Targeting of Nuclear Protein Import in Pathological Cell Conditions
Pharmacological Reviews, 10/15/09
Chahine MN et al. – Proteins enter the nucleus through the nuclear pore complex. Once in the nucleus, some proteins, such as transcriptional regulators, can turn genes on or off, and change the composition of the cell and its function to meet the demands of its environment. This process of protein import into the nucleus is highly controlled and regulated by the expression or function of single cargoes, transport receptors, or the transport channels themselves.
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