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See Latest ArticlesThe Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not
Pharmacological Reviews, 10/15/09
Romanovsky AA et al. – The development of antagonists of the transient receptor potential vanilloid–1 (TRPV1) channel as pain therapeutics has revealed that these compounds cause hyperthermia in humans. This undesirable on–target side effect has triggered a surge of interest in the role of TRPV1 in thermoregulation and revived the hypothesis that TRPV1 channels serve as thermosensors.
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