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See Latest ArticlesRelationship of CYP2D6 genetic polymorphisms and the pharmacokinetics of tramadol in Chinese volunteers
Journal of Clinical Pharmacy and Therapeutics, 10/05/09
Li Q et al. – CYP2D6*2 does not alter the pharmacokinetics of tramadol, whereas CYP2D6*10 did with homozygotes showing a more pronounced reduction than heterozygotes. The 32–h metabolic ratio of tramadol to M1 were (mean ± SD) 2·05 ± 1·01, 2·13 ± 0·83, 4·24 ± 2·75 and 6·85 ± 2·78, respectively, in CYP2D6*1/*1, CYP2D6*2/*2, CYP2D6*2/*10 and CYP2D6*10/*10 subjects, respectively.
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