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Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis
The Journal of Infectious Diseases, 10/05/09
Duan R et al. – Corneal HSV–1 isolates are mixtures of acyclovir–sensitive and acyclovir–resistant viruses that share the same genotype but have different TK sequences. Recovery of the same acyclovir-resistant virus during consecutive herpetic keratitis episodes suggests that acyclovir–resistant HSV–1 establishes latency and reactivates intermittently to cause acyclovir–refractory RHK.
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