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See Latest ArticlesExploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan
Drug Metabolism and Disposition, 10/05/09
Bonn BK et al. – The inhibition studies showed evidence for strong reversible inhibition of CYP2D6 but not for CYP3A4. Levallorphan acted as a time dependent inhibitor on CYP3A4 indicating a productive binding mode with this enzyme not observed with CYP2D6 that presumably resulted from close interactions of the N–allyl moiety oriented towards the heme.
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