Pharmacy Medical News about Chloroquine

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Cardiotoxicity after low-dose chloroquine antimalarial therapy
Heart and Vessels, 10/06/09

Fragasso G et al. – The authors describe a patient with recurrent malaria, prophylactically treated with low–dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction. The right ventricle endomyocardial biopsy was suggestive of chloroquine toxicity. The heart failure improved after drug withdrawal. As a consequence, the potential for reversibility and the severity in undiagnosed cases of these toxic cardiomyopathies emphasize the importance of recognizing early signs of toxicity in order to withdraw antimalarials before the occurrence of life–threatening cardiac toxicity.

Exclusive Author Commentary
Gabriele Fragasso, 10/07/09

The article outlines the possibility that chloroquine, also at low doses, can be cardiotoxic. For those physicians often prescribing this agent, this appears as a useful information to be kept in mind in the follow-up of their patients.

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Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial
Malaria Journal, 10/26/09 Relevance Score: 87%

Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome
Journal of Molecular and Cellular Cardiology, 10/20/09 Relevance Score: 84%

Does chloroquine therapy of porphyria cutanea tarda influence liver pathology
International Journal of Dermatology, 11/13/09 Relevance Score: 83%

Therapeutic efficacy of chloroquine and sequence variation in pfcrt gene among patients with falciparum malaria in central India
Tropical Medicine & International Health, 11/13/09 Relevance Score: 80%

Drugs for preventing malaria in travellers
Cochrane Reviews, 10/23/09 Relevance Score: 80%