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See Latest ArticlesInhibition of Presynaptic Release-Facilitatory Kainate Autoreceptors by Extracellular Cyclic GMP
Journal of Pharmacology and Experimental Therapeutics, 10/09/09
Cervetto C et al. – Extracellular cGMP inhibited the neurotransmitter release evoked by presynaptic kainate receptor activation; the inhibitory effect of extracellular cGMP was selective for the kainate autoreceptor–mediated response and did not affect the AMPA autoreceptor–mediated response. Endogenously synthesized cGMP might be the physiological source for the extracellular cGMP modulating the response to kainate autoreceptor activation.
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