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Yeomans NY et al. – Data suggest that ASA causes significant gastroduodenal damage even at the low doses used for cardiovascular protection. These effects (both systemic and possibly local) may be pharmacodynamically distinct from the gastroduodenal toxicity seen with NSAIDs. Studies are required to establish strategies for improving the tolerability of low–dose ASA, allowing patients to continue to benefit from the cardiovascular protection associated with such therapy.

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