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Delmonte A et al. – VDAs specifically target and destroy well–established tumor vessels with ischemia and destruction of large masses with central hemorrhagic necrosis and survival of a thin peripheral tumor layer. VDAs can be divided into biologics, such as ligand–based, and small–molecule agents; this second group includes small–molecule VDAs like flavonoids, such as 5,6–dimethylxanthenone–4–acetic acid (DMXAA), and microtubule–destabilizing agents.


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