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Dubovsky SL et al. – Agomelatine appears to be well tolerated, without sexual or cardiac adverse effects, weight gain or discontinuation syndromes. Substantially more research is needed to establish its role in the treatment of mood and circadian rhythm disorders.

Exclusive Author Commentary
Steven L Dubovsky?, 10/10/09

It remains to be seen whether this medication has distinct advantages over existing medications, but it could be most appropriate for mild to moderate depression associated with sleep onset insomnia.

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