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See Latest ArticlesNicotine metabolism in African Americans and European Americans: variation in glucuronidation by ethnicity and UGT2B10 haplotype
Journal of Pharmacology and Experimental Therapeutics, 10/08/09
Berg JZ et al. – Two key outcomes are reported here. First, the observation that African Americans have lower nicotine and cotinine glucuronidation was confirmed in a population of abstinent smokers on the nicotine patch. In addition, the authors provide the first convincing evidence that UGT2B10 is a key catalyst of these glucuronidation pathways in vivo.
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