Pharmacy Medical News about Arthritis, Rheumatoid

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Sharma S et al. – Genes from all the three pathways seem to contribute to MTX response in the Indian population.

Methods

RA patients recruited using American College of Rheumatology criteria
Grouped into good (n = 213) and poor (n = 68) responders to MTX, based on Disease Activity Score 28-3
Individual single nucleotide polymorphism association was tested using ?2 test
Cumulative contribution of all single-nucleotide polymorphisms and cumulative contribution of all SNPs and clinico-demographic factors assessed using linear and logistic regression

Results

G allele of ADA rs244076 [P = 0.02, odds ratio (95% confidence interval): OR (95% CI) = 1.66 (1.01-2.75)]; and T allele of ADORA2A rs5751876 [P = 0.04, OR (95% CI) = 1.55 (1.01-2.37)] were associated with poor response, but did not stand Bonferroni correction
On regression analyses, FPGS rs1544105, TYMS rs2853539, DHFR rs7387, and ADA rs244076 were identified as putative predictors for MTX response
Carriers of the FPGS rs1544105 AA and AG genotypes [OR (95% CI) = 3.47 (1.19-10.12)] and TYMS rs2853539 AA genotype [OR (95% CI) = 2.76 (1.50-5.07)] were predictors of poor response in patient population