Pharmacy Medical News about Warfarin

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Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy
Pharmacogenetics and genomics, 09/30/09

Zhang JE et al. – Although the authors were unable to demonstrate an association between rs2108622 and stable warfarin dose, the finding of an association between rs2189784 and time–to–therapeutic international normalized ratio is consistent with the recent finding that CYP4F2 plays a role in vitamin K metabolism. However, the effect of CYP4F2 is relatively small in all studies undertaken so far, and thus seems unlikely to be of clinical relevance.

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Safety of Concomitant Tamoxifen and Warfarin
Annals of Pharmacotherapy, 10/21/09 Relevance Score: 90%

Long-term oral anticoagulation therapy and the risk of hip fracture in patients with previous hemispheric infarction and nonrheumatic atrial fibrillation
Cerebrovascular Diseases, 11/12/09 Relevance Score: 89%

Use of Chromogenic Assay of Factor X to Accept or Reject INR Results in Warfarin Treated Patients
Clinical Medicine & Research, 10/09/09 Relevance Score: 87%

Gastrointestinal Safety of Nonsteroidal Antiinflammatory Drugs and Selective Cyclooxygenase-2 Inhibitors in Patients on Warfarin
Annals of Pharmacotherapy, 10/13/09 Relevance Score: 85%

Uninterrupted Warfarin for Periprocedural Anticoagulation in Catheter Ablation of Typical Atrial Flutter: A Safe and Cost-Effective Strategy
Journal of Cardiovascular Electrophysiology, 10/06/09 Relevance Score: 85%